DERIVATIVES OF AROMATIC AMINES ELICITING EFFECT INHIBITING OAC, METHOD OF THEIR SYNTHESIS AND INHIBITOR OF нOAC Russian patent published in 2002 - IPC

FIELD: organic chemistry. SUBSTANCE: invention relates to novel derivatives of aromatic amines of the general formula (1) eliciting effect inhibiting OAC and to method of their synthesis and inhibitor of нOAC. Invention describes compounds of the general formula (1) where R₁, R₂, R₃, R₄ have similar or different values and taken among hydrogen atom, lower alkyl possibly substituted with halogen atom, phenyl possible substituted with halogen atom, lower alkyl, cyclic alkyl group with 3-8 carbon atoms; or R₁ and R₂ can in common form 3-8-membered ring; or R₃ and R₄ in common form monocyclic or condensed ring with 3-10 carbon atoms; X₁, X₂, X₃, X₄, X₅, X₆, X₇, X₈, X₉ can be similar or different and taken among hydrogen atom and other values, respectively; A means substituted benzene or 5-6-membered aromatic heterocyclic ring possibly having substitutes; n and m each is a whole number = 0 or 1 under condition indicated in the invention claim or their possible tautomers, stereomers or optically active forms and pharmaceutically acceptable salt. Invention relates also to inhibitor of нOAC comprising the above indicated compounds and pharmaceutically acceptable carrier or diluting agent. Method of synthesis involves interaction of compound of the formula (2) with compound A-у₁, where Y and у₁ are different and mean NHR₅ or L where L is removal group. EFFECT: improved method of synthesis, valuable properties. 19 cl, 81 tbl