FIELD: biotechnology.
SUBSTANCE: invention relates to biotechnology, specifically to novel peptides based on human lactoferrin, and can be used in medicine. Method includes synthesis of peptides, characterised by sequence CFLWRRLMRKLR (SEQ ID NO: 74);CWLWRRAMRKVW (SEQ ID NO: 76); LRLWRRLMRKVW (SEQ ID NO: 77);RRLWRRWMRKVL (SEQ ID NO: 78); CRLWRRRMRKVW (SEQ ID NO: 79); LRLWRRSMRKVW (SEQ ID NO: 81); KKLWRRWWRKVL (SEQ ID NO: 90); RWCKLWRRLMRKVRRL (SEQ ID NO: 85);RWCFLWRRLMRKHRRL(SEQ ID NO: 86); WCKLWRRLMRKVRR(SEQ ID NO: 87); WRRWLRKSVKRL(SEQ ID NO: 93); WCRWLRKMVKAL(SEQ ID NO: 94) or WRRWLRKMVKRL(SEQ ID NO: 95).
EFFECT: disclosed peptides are capable of effectively inhibiting synthesis of TNF-α in stimulated human LPS monocytes, which enables use thereof in therapy of infections or inflammation of skin and skin structures.
7 cl, 5 dwg, 9 tbl, 5 ex
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