PEPTIDES WITH ANTAGONISTIC ACTIVITIES AGAINST NATURAL CXCR4 Russian patent published in 2018 - IPC A61K38/10 

FIELD: biochemistry.

SUBSTANCE: invention relates to biochemistry. Described is a group of inventions comprising a peptide and a dimeric peptide capable of blocking the infection of X4-tropic NL4-3 HIV-1 with an IC₅₀ value less than 50 mcM, the use of said peptides for the treatment of neurological diseases, the use of said peptides for the treatment of wounds and methods for the preparation of said peptides. In one embodiment, the peptide comprises an amino acid sequence selected from the group consisting of: IVRFTKKVPQVS, 408I-419 Y411F; IVRWTKKVPQVS, 408I-419 Y411W; IVRYSKKVPQVS, 408I-419 T412S; IVRYTKCVPQVS, 408I-419 K414C; IVRYSKKVPQC, 408I-418 SC; IVRWTKKVPQVC, 408I-419 WC01; IVRWTCKVPQVS, 408I-419 WC02; IVRWCKKVPQVS, 408I-419 WC03; IVRWSKKVPQCS, 408I-419 WSC01; IVRWSKKVPCVS, 408I-419 WSC02; IVRWSKKVCQVS, 408I-419 WSC03; IVRYTKKVPQCS, 408I-419 V418C.

EFFECT: invention widens the range of drugs that can block X4-tropic NL4-3 HIV-1 infection.

6 cl, 1 tbl, 19 ex