MULTIFUNCTIONAL NITROXIDE DERIVATIVES AND USES THEREOF Russian patent published in 2016 - IPC C07D207/46 C07D211/94 C07D223/12 C07D401/12 A61K31/40 A61K31/4439 A61K31/444 A61K31/55 A61P9/10 A61P39/00 

FIELD: pharmaceutics.

SUBSTANCE: invention provides multifunctional nitric oxide derivatives of formula I: I, where Y is N, CH or N(→O), or its enantiomer, diastereomers, racemic mixture or its pharmaceutically acceptable salt or solvate, where A is a fragment of general formula II connected through its terminal -NH group with any atom of carbon of pyridine, phenyl or pyridine-oxide ring: II; X is absent or is -(CR₂R₂)_n-; R₁ is absent or is represented by from 1 to 5 substituents, each of which is independently selected from a halogen, -CN, -OH, -NO₂, -N(R₆)₂, -OCF₃, -CF₃, -OR₆, -COR₆, -COOR₆, -CON(R₆)₂, -OCOOR₆, -OCON(R₆)₂, -(C₁-C₈)alkyl, -(C₁-C₈)alkylen-COOR₆, -SR₆, -SO₂R₆, -SO₂N(R₆)₂ or -S(=O)R₆; R₂ is H; R₃ each independently represents a (C₁-C₈)alkyl; R₄ is selected from H or -(C₁-C₈)alkyl; R₅ is selected from H or -CN; R₆ each is independently selected from H or (C₁-C₈)alkyl and n is an integer equal to 1 or 2.

EFFECT: said compounds contain a potassium channels opener and a catalyst for degradation of reactive forms of oxygen (RFO), which can act as an antioxidant; also proposed are pharmaceutical compositions containing the said compounds, which can be used for treating diseases, disorders or conditions related to oxidative stress or endothelial dysfunction.

19 cl, 9 dwg, 5 tbl, 14 ex