PRODRUGS OF MULTIFUNCTIONAL NITROXIDE DERIVATIVES AND USES THEREOF Russian patent published in 2018 - IPC C07D207/46 C07D211/94 C07D223/04 A61K31/40 A61K31/445 A61K31/55 A61P11/00 A61P13/12 A61P29/00 

Abstract RU 2659220 C2

FIELD: chemistry.

SUBSTANCE: invention relates to prodrugs of compounds comprising a nitric oxide donor and a reactive oxygen species (ROS) degradation catalyst, in particular, 1-pyrrolidinyloxy, 1-piperidinyloxy, and 1-azepanyloxy derivatives, and pharmaceutical compositions containing same. .

EFFECT: said compounds and pharmaceutical compositions are suitable for prevention, treatment or management of diseases, disorders or conditions associated with oxidative stress or endothelial dysfunction.

17 cl, 7 dwg, 11 tbl, 17 ex

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RU 2 659 220 C2

Authors

Zaltsman Endryu Luri

Dzhagtap Prakash

Sauzan Garri Dzhon

Dates

2018-06-29Published

2014-03-05Filed