METHOD FOR PREDICTION OF INDIVIDUAL CLINICAL EFFECTIVENESS OF STATINS (VERSIONS) Russian patent published in 2016 - IPC A61B5/00 G01N33/48 

FIELD: medicine.

SUBSTANCE: group of inventions relates to medicine, namely to therapy, pharmacology, cardiology, pathophysiology, biochemistry and can be used for prediction of individual clinical effectiveness of statins. For patients with normal weight the following is determined: age, BMI, deviation as per Broca constant, blood circulation economization constant, total cholesterol, very low-density lipoprotein cholesterol, glucose, creatine kinase, soluble fibrin-monomer complexes, Von Willebrand factor. Discriminant function (d) value is calculated by formula. If the d value is less than -0.034, absence of individual clinical effectiveness of statins is predicted. If the d value is equal to -0.034, same probability of presence or absence of therapeutic effect is predicted. If the d value is more than -0.034, presence of individual clinical effectiveness of statins is predicted. For patients with overweight the following is determined: deviation as per Broca constant, blood circulation economization constant, total cholesterol, glucose, creatine kinase, soluble fibrin-monomer complexes, albumin. Value of d is calculated by formula. If the d value is less than -0.391, absence of individual clinical effectiveness of statins is predicted. If the d value is equal to -0.391, same probability of presence or absence of therapeutic effect is predicted. If the d value is more than -0.391, presence of individual clinical effectiveness of statins is predicted. For patients suffering obesity the following is determined: BMI, deviation as per Broca constant, blood circulation economization constant, total cholesterol, very low-density lipoprotein cholesterol, glucose, creatine kinase, soluble fibrin-monomer complexes, albumin, alanine transaminase, disturbed tolerance to carbohydrates. Value of d is calculated by formula. If the d value is more than -0.281, absence of individual clinical effectiveness of statins is predicted. If the d value is equal to -0.281, same probability of presence or absence of therapeutic effect is predicted. If the d value is less than -0.281, presence of individual clinical effectiveness of statins is predicted.

EFFECT: group of inventions allows making reliable and efficient prediction of individual clinical effectiveness of statins, in-time implementation of other methods of treatment due to assessing the most significant set of indicators.

3 cl, 3 dwg, 3 tbl, 6 ex