AMPHIPHILIC COPOLYMERS AND SYNTHESIS METHOD THEREOF Russian patent published in 2016 - IPC C08F226/10 C08F220/56 C08F220/06 C08F2/06 B82Y5/00 

FIELD: chemistry.

SUBSTANCE: invention relates to organic high-molecular compounds, specifically to new biocompatible amphiphilic random copolymers suitable for creation of medicinal preparations, biologically active substances and solubilisation of poorly soluble substances, as well as a single-step method of producing such copolymers. Amphiphilic random copolymer contains at least two different monomers, selected from a group comprising N-vinylpyrrolidone, N-isopropylacrylamide, N-(2-hydroxypropyl)methacrylamide, ethyleneamine, 2-allyloxybenzaldehyde, acrylamide, acrylic acid and esters thereof, methacrylic acid and esters thereof, N-dialkylacrylamide, and includes a group of general structure where z is an integer from 8 to 19; X is NH₂, NH₃Cl. Number-average molecular weight of copolymer varies from 1 to 30 kDa. Method of producing said copolymer comprises radical copolymerisation of monomers in an organic solvent in presence of a copolymerisation radical initiator. During copolymerisation a chain length growth regulator is used in form of long-chain aliphatic mercaptoamine or mercaptoamine chloride.

EFFECT: invention provides a single-step method of producing amphiphilic random copolymers, increases output of end product, and reduces production time thereof.

9 cl, 6 tbl, 5 ex