AMPHIPHILIC POLYMER-METAL COMPLEXES AND SYNTHESIS METHOD THEREOF Russian patent published in 2017 - IPC C08F126/10 C08F226/10 C08F120/56 C08F220/56 C08F120/06 C08F220/06 B82Y5/00 A61K9/16 A61K47/48 A61P35/00 

FIELD: chemistry.

SUBSTANCE: invention relates to organic high-molecular compounds, and specifically to novel amphiphilic polymer complexes, a method for production thereof, to a carrier and a composition for delivery of biologically active substances, as well as use of complexes as activators of oxo-biodegradation of carbochain polymers. Polymer complex contains a hydrophilic fragment of an amphiphilic polymer, which is bonded to transition metal ions. Amphiphilic polymer is a homopolymer or random copolymer of general formula H-[-M-]-S-R, wherein [-M-] is a hydrophilic fragment consisting of identical or several different irregularly ordered monomers, selected from a group comprising N-vinylpyrrolidone, N-isopropylacrylamide, N-(2-hydroxypropyl)methacrylamide, ethyleneamine, 2-allyloxybenzaldehyde, acrylamide, N-dialkylacrylamide, maleic anhydride, acrylic, methacrylic, maleic, fumaric, cinnamic acid and esters of said acids; R is a hydrophilic fragment of general structure –(-C_8-19alkyl)-CH₂-X, where X independently represents H, OH, NH₂ or NH₃Cl. In amphiphilic polymer at least 1 mol% of monomers are monomers, containing a carboxyl group. Number average molecular weight of amphiphilic polymer ranges from 1 to 30 kDa. Method of producing polymer complexes involves combined incubation of aqueous solution of amphiphilic polymer with aqueous or organic solution of a transition metal salt. Carrier for delivery of biologically active substances is micelles, consisting of said complexes. Composition for delivery of biologically active substances contains at least one biologically active substance and said carrier.

EFFECT: invention enables to obtain polymer complexes with high output and high degree of purity, and also to obtain a carrier ensuring high water compatibility of poorly soluble and insoluble biologically active substances.

11 cl, 3 dwg, 2 tbl, 9 ex