FIELD: chemistry.
SUBSTANCE: invention relates to organic high-molecular compounds, specifically to new biocompatible amphiphilic homopolymers suitable for creation of medicinal preparations, biologically active substances and solubilisation of poorly soluble substances, as well as a single-step method of producing such homopolymers. Amphiphilic homopolymers have general formula 
, where M is a monomer selected from a group comprising N-vinylpyrrolidone, N-isopropylacrylamide, N-(2-hydroxypropyl)methacrylamide, ethyleneamine, 2-allyloxybenzaldehyde, acrylamide, acrylic acid and esters thereof, methacrylic acid and esters thereof and N-dialkylacrylamide; R is a long-chain aliphatic linear or branched hydrophobic group; n is an integer from 6 to 125. Method of producing said homopolymers comprises performing radical homopolymerisation of a monomer in an organic solvent in presence of a radical homopolymerisation initiator and chain length growth regulator. Chain length rowth regulator is long-chain aliphatic mercaptoamine or muriatic mercaptoamino chloride.
EFFECT: invention provides a single-step method of producing amphiphilic homopolymers, increases output of end product, and reduces production time thereof.
9 cl, 6 tbl, 4 ex
| Title | Year | Author | Number |
|---|---|---|---|
| AMPHIPHILIC COPOLYMERS AND SYNTHESIS METHOD THEREOF | 2014 |
|
RU2599579C2 |
| METHOD OF PRODUCING HYBRID TWO-PHASE SYSTEM OF DELIVERY OF POORLY SOLUBLE AND INSOLUBLE IN WATER BIOLOGICALLY ACTIVE SUBSTANCES WITH CONTROLLED RELEASE KINETIC | 2015 |
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| WATER-COMPATIBLE POLYMER COMPOSITIONS FOR DELIVERY OF BIOLOGICALLY ACTIVE SUBSTANCES | 2015 |
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| METHOD OF PRODUCING AMPHIPHILIC RANDOM COPOLYMERS | 2017 |
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|
RU2266103C2 |
| 0 |
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SU425403A3 | |
| METHOD OF PRODUCING GRAFT COPOLYMERS BASED ON SODIUM POLY(ASPARTATE) AND OBTAINED GRAFT COPOLYMERS | 2009 |
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RU2485141C2 |
