METHOD OF PRODUCING IMIDOYL CHLORIDES Russian patent published in 2016 - IPC C07C249/02 C07C251/24 

FIELD: chemistry.

SUBSTANCE: invention relates to synthesis of imidoylchlorides, which are intermediates in synthesis of biologically active chemical compounds used in synthesis of medicinal preparations, namely, to a novel method of producing N-arylbenzimidoylchloride. Method of producing imidoylchlorides derivatives of general formula (I), where R=-H, -CH₃ (m, n), -OCH₃ (n), Cl (n), is carried out by reacting N-arylamide with a chlorinating agent at 75-80 °C during 1 hour followed by extraction of the reaction product. Herewith N-arylamide derivative used is a N-arylbenzamide derivative and the chlorinating agent used is phosphorus trichloride, and the reaction is carried out in presence of a nitrogen-containing heterocyclic catalyst selected from pyridine, 4-(N,N-dimethylamino)pyridine or N-methylimidazole at the molar ratio of N-arylbenzamide, phosphorus trichloride and the catalyst of 1:5:1.

EFFECT: simpler method of producing N-arylbenzimidoylchloride while maintaining high output of products.

1 cl, 9 ex