METHOD OF PRODUCING 1-CHLOROADAMANTYL-3-FORMAMIDE (1-CHLOROADAMANTYL-3-CARBOXYLIC ACID AMIDE) Russian patent published in 2012 - IPC C07C231/14 C07C233/57 

FIELD: chemistry.

SUBSTANCE: invention relates to organic chemistry and particularly to a method of producing 1-chloroadamantyl-3-carboxylica acid amide used in synthesis of 1,3-disubstituted adamantane derivatives and as starting material when producing medicinal agents. The method involves simultaneous chlorination and amidation of adamantyl-1-carboxylic acid or acid chloride thereof with chlorinating agents and acetonitrile in the presence of a catalyst, where the chlorinating agent used is carbon tetrachloride and the catalyst is VO(acac)₂, in the presence of water at temperature 125-150°C for 1-3 hours in molar ratio [VO(acac)₂] : [Ad-R] : [CH₃CN] : [H₂O] : [CCl₄] = 1 : (100-1000) : (100-1000) : (100-1000) : (200-2000), where (R-COOH, COCl).

EFFECT: achieving high output (95%) of 1-chloroadamantyl-3-formamide with 100% conversion of adamantyl-1-carboxylic acid or acid chloride thereof.

1 cl, 15 ex, 1 tbl