FIELD: medicine.
SUBSTANCE: invention relates to medicine, namely to organ transplantation and clinical laboratory diagnostics, and can be used for immune suppressive therapy following liver transplantation in children at early age. For this purpose 3-4 weeks after liver transplantation concentration of transforming growth factor beta 1 (TGF-β1) is measured in children's blood plasma, ng/ml. Then daily dose of tacrolimus is calculated: at concentration of TGF β1 equal to or more than 9.5 ng/ml, daily dose of tacrolimus is prescribed in range of 0.4-2.5 mg, while at concentration of TGF-β1 less than 9.5, daily dose of tacrolimus is prescribed in range of 3.0 to 6.0 mg.
EFFECT: use of given method enables individual selection of immunosuppressor tacrolimus concentration one month after liver transplantation.
1 cl, 5 ex
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