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IPC

G01N33/49(2006-01-01)

A61K31/56(2006-01-01)

A61K38/13(2006-01-01)

A61P37/06(2006-01-01)

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Application

2015151044, 2015-11-27

(24)

Start date

2015-11-27

(22)

Actual filing date

2015-11-27

(45)

Published

2017-05-12

(72)

Inventor

Kurabekova Rivada MusabekovnaTsirulnikova Olga MartenovnaShevchenko Olga PavlovnaTsirulnikova Irina EvgenevnaGichkun Olga EvgenevnaGote Sergej Vladimirovich

(73)

Holder

Federalnoe Gosudarstvennoe Byudzhetnoe Uchrezhdenie Nauchnyj Tsentr Transplantologii I Iskusstvennykh Organov Imeni Akademika V.I. Shumakova" Ministerstva Zdravookhraneniya Rossijskoj Federatsii

METHOD OF SELECTING THE IMMUNOSUPPRESSION REGIME TO CHILDREN OF EARLY AGE IN A REMOTE PERIOD AFTER TRANSPLANTATION OF THE LIVER Russian patent published in 2017 - IPC G01N33/49 A61K31/56 A61K38/13 A61P37/06

Abstract RU 2619216 C1

FIELD: medicine.

SUBSTANCE: one year after transplantation in blood serum, the content of insulin-like growth factor 1 (IGF-1) and soluble CD30 (sCD30) is determined in liver recipients, and the dose of tacrolimus is adjusted to the specific concentration of IGF-1 and sCD30, the daily dose of tacrolimus is determined by formula D=1.3764+0.0081×G-0.0026×C, where D is the daily dose of tacrolimus, mg; G - serum level of IGF-1, ng/ml; C - content of sCD30 in serum, ng/ml.

EFFECT: use of this method allows for effective prevention of complications in young children after liver transplantation for congenital diseases of the hepatobiliary system in the long-term due to individual selection of tacrolimus concentration one year after liver transplantation.

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RU 2 619 216 C1

Authors

Kurabekova Rivada Musabekovna

Tsirulnikova Olga Martenovna

Shevchenko Olga Pavlovna

Tsirulnikova Irina Evgenevna

Gichkun Olga Evgenevna

Gote Sergej Vladimirovich

Dates

2017-05-12—Published

2015-11-27—Filed