PROCESSES FOR MAKING COMPOUNDS USEFUL AS INHIBITORS OF ATR KINASE Russian patent published in 2019 - IPC C07D413/04 A61K31/497 C07D413/14 A61P35/00 

Abstract RU 2677292 C2

FIELD: chemistry.

SUBSTANCE: invention relates to a solid form of the compound of formula I-2, wherein the form is selected from the group consisting of crystalline free base of compound I-2, characterized by peaks expressed in 2-theta ±0.2 at about 14.2, 25.6, 18.1, 22.0 and 11.1 degrees in a X-ray powder diffraction pattern obtained using Cu K alpha radiation, or crystalline compound I-2 • HCl, characterized by peaks expressed in 2-theta ±0.2 at about 13.5, 28.8, 15.0, 18.8 and 15.4 degrees in a X-ray powder diffraction pattern obtained when using Cu K alpha radiation.

I-2.

EFFECT: according to the invention the compound of formula I-2 has the ability to inhibit ATR kinase and is used for the production of a medicament for treating pancreatic cancer or non-small cell lung cancer, and is also stable.

18 cl, 20 dwg, 18 ex

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RU 2 677 292 C2

Authors

Sharre Zhan-Damen

Stadli Dzhon

Perar Fransuaz Ivonn Teodora Mari

Darrant Stiven Dzhon

Littler Bendzhamin Dzhozef

Khyuz Robert Majkl

Sisel Devid Endryu

Ejndzhell Pol

Urbina Armando

Shi I

Dates

2019-01-16Published

2012-09-28Filed