FIELD: chemistry.
SUBSTANCE: invention relates to dual functional conjugate of formula i, where docetaxel is linked with muramyl dipeptide derivative, which enables to achieve anticancer and antimetastatic effect. Method of producing conjugate is carried out by combination of solid-phase and liquid-phase synthesis.
EFFECT: invention also discloses a pharmaceutical composition and use of conjugate for producing anti-tumour drugs.
21 cl, 29 dwg, 13 tbl, 51 ex
| Title | Year | Author | Number |
|---|---|---|---|
| CHEMICAL SYNTHESIS AND ANTI-TUMOR AND ANTI-METASTATIC EFFECTS OF CONJUGATE OF DOUBLE ACTION | 2011 |
|
RU2729419C2 |
| PEPTIDE COMPOUND CAPABLE OF BINDING WITH PSMA, METHOD FOR PRODUCTION AND USE THEREOF | 2021 |
|
RU2823164C2 |
| COMPOUNDS FOR TREATING CANCER | 2011 |
|
RU2609018C2 |
| CXCR7 ANTAGONISTS | 2013 |
|
RU2649004C2 |
| PD-L1 ANTAGONIST COMPOUND | 2020 |
|
RU2823231C1 |
| SUBSTITUTED 2-METHYLIDEN-5-(PHENYLAMINO)-2,3-DIHYDROTIOPHEN-3-ONE FOR TREATMENT OF LEUKEMIAS WITH TRANSLOCATIONS OF MLL-GENE AND OTHER ONCOLOGICAL DISEASES | 2017 |
|
RU2656603C1 |
| AZAINDAZOLE OR DIAZAINDAZOLE DERIVATIVES AS MEDICINE | 2012 |
|
RU2600976C2 |
| AGENT FOR INHIBITING THE HUMAN TYROSYL-DNA-PHOSPHODIESTERASE 1 ENZYME BASED ON PENTAFURANOSYL NUCLEOSIDE DERIVATIVES | 2019 |
|
RU2748103C1 |
| TARGETING CANCER TUMOURS BY APPLICATION OF INHIBITORS OF CARBONIC ANHYDRASE IX ISOFORMS | 2011 |
|
RU2568115C2 |
| METHOD OF OBTAINING DISPIROINDOLINONES | 2018 |
|
RU2682678C1 |
