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(19)

(11)

2 604 804

(13)

(51)

IPC

C12N5/71(2010-01-01)

C12N5/16(2006-01-01)

G01N33/569(2006-01-01)

(21) (22)

Application

2015155737/10, 2015-12-25

(24)

Start date

2015-12-25

(22)

Actual filing date

2015-12-25

(45)

Published

2016-12-10

(72)

Inventor

Klabukova Darja LeonidovnaMashentseva Natalja GennadevnaNikonov Ilja NikolaevichFisinin Vladimir IvanovichChebotareva Svetlana EgorovnaChebotarev Ivan Izotovich

(73)

Holder

Obshchestvo S Ogranichennoj Otvetstvennostju

METHOD OF DETERMINING SAFETY OF PROBIOTIC MICROORGANISMS USING CELL TEST SYSTEMS Russian patent published in 2016 - IPC C12N5/71 C12N5/16 G01N33/569

Abstract RU 2604804 C1

FIELD: biotechnology.

SUBSTANCE: invention relates to biotechnology. Method of determining safety of probiotic microorganisms is disclosed, in which test systems are cell cultures of mammals and human. Method involves three stages: preparation of analyzed object, preparation of test system and determination of safety of object for test system. Toxicity and toxigenicity of probiotic microorganisms are evaluated on basis of cell culture vitality determination using Goryaev's chamber.

EFFECT: invention provides higher accuracy and reliability of results of determination of safety of probiotic microorganisms for humans.

1 cl, 4 tbl, 1 ex

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RU 2 604 804 C1

Authors

Klabukova Darja Leonidovna

Mashentseva Natalja Gennadevna

Nikonov Ilja Nikolaevich

Fisinin Vladimir Ivanovich

Chebotareva Svetlana Egorovna

Chebotarev Ivan Izotovich

Dates

2016-12-10—Published

2015-12-25—Filed