FIELD: medicine.
SUBSTANCE: method for inhibition or neutralisation of the alpha chain activity of the colony-stimulating granulocyte/macrophage (GM-CSFRα) factor in a patient, comprising administration of a composition containing an effective amount of an antibody to human GM-CSFRα. In addition, methods for treatment of rheumatoid arthritis, asthma, chronic obstructive pulmonary disease or myeloid leukaemia in a patient are contemplated. This invention may find use in the therapy of other diseases associated with GM-CSFRα.
EFFECT: increased efficiency of treatment.
12 cl, 9 dwg, 5 tbl
| Title | Year | Author | Number |
|---|---|---|---|
| GM-CSF RECEPTOR BINDER | 2007 |
|
RU2495050C2 |
| OSTEOARTHRITIS TREATMENT | 2009 |
|
RU2712273C2 |
| ANTI-GM-CSF ANTIBODIES AND USING THEM | 2006 |
|
RU2447085C2 |
| ANTIBODIES TO HUMAN NKG2D AND THEIR APPLICATION | 2008 |
|
RU2563343C2 |
| RECOVERED HUMAN ANTIBODY OR ITS ANTIGEN-BINDING FRAGMENT (VERSIONS), METHOD OF TREATING hTNFα-MEDIATED DISEASES WITH MEDIATION THEREOF (VERSIONS), PHARMACEUTICAL COMPOSITION, RECOMBINANT HUMAN ANTIBODY OR ITS ANTIGEN-BINDING FRAGMENT, RECOVERED NUCLEIC ACID (VERSIONS) | 2005 |
|
RU2458704C9 |
| MONOCLONAL ANTIBODIES BINDING WITH hGM-CSF AND COMPOSITIONS FOR MEDICINAL PURPOSES, CONTAINING THEREOF | 2008 |
|
RU2517596C2 |
| ANTI-CXCR4 ANTIBODIES AND ANTIBODY-DRUG CONJUGATES | 2014 |
|
RU2675516C2 |
| MOLECULES WHICH BIND TO 4-1BB | 2011 |
|
RU2710717C2 |
| PAIN TREATMENT | 2009 |
|
RU2630969C2 |
| RECOVERED IP-10 ANTIBODY, IMMUNOCONJUGATE AND BIOSPECIFIC MOLECULE THEREOF, COMPOSITIONS THEREOF, METHOD OF TREATING (VERSIONS), CODING MOLECULE OF NUCLEIC ACID, RELATIVE EXPRESSION VECTOR, HOST CELL AND HYBRIDOMA | 2004 |
|
RU2486199C2 |
