QUINOLINE AND QUINOXALINE DERIVATIVES EFFECTIVE AS CYSTEINYL-LEUKOTRIENE ANTAGONISTS Russian patent published in 2016 - IPC C07D215/18 C07D241/42 C07D401/12 C07D401/14 A61K31/47 A61K31/4709 A61K31/498 A61K31/4427 A61P11/06 

Abstract RU 2605929 C2

FIELD: chemistry.

SUBSTANCE: invention relates to organic chemistry, specifically to a heterocyclic compound of formula (IA) or to a pharmaceutically acceptable salt thereof, where in each case R1 and R3 are independently selected from a group comprising hydrogen, halogen, -OH, -C1-2alkyl, -O-C1-2alkyl, -O-C1halogenalkoxy, -N(C1alkyl)2; R2 represents hydrogen; W represents a group selected from -CH= or -N=; X represents a group selected from -CH=CH- or -N=CH-, where nitrogen from -N=CH- is directly bonded with ring 'a'; Y represents a group selected from -CH=CH- or -C≡C-; Z denotes a bond or group selected from -(CH2)n- and -CH=CH-; A is a group selected from -OR, -O(CH2)nphenyl, -O(CH2)nthiophene; P is selected from a group comprising -O-; Q is a group selected from -COOH; where R is selected from a group comprising hydrogen, -C1-6alkyl, -C3-6cycloalkyl, -C1alkyl (C3-6cycloalkyl), -C3-6alkenyl and -C3-6alkynyl; 'n' in each case represents an integer, selected from 1, 2 or 3; 'm' in each case represents an integer, selected from 0-3, inclusive. Invention also relates to a compound of formula (Id), where radicals are described in patent claim.

EFFECT: obtaining novel heterocyclic compounds effective as antagonists of cysteinyl-leukotriene.

9 cl, 1 dwg, 2 tbl, 67 ex

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RU 2 605 929 C2

Authors

Rathod Rajendrasinh

Bhatt Tushar

Joshi Kiritkumar

Dole Binaka

Murty Kadiyala V.S.N

Thennati Rajamannar

Dates

2016-12-27Published

2012-07-26Filed