FIELD: medicine.
SUBSTANCE: group of inventions refers to medicine, in particular to oncology, and describes a biocompatible nanomaterial and method of its production. Proposed biocompatible nanomaterial is a hybrid associates of colloidal quantum dots CdS with average size of 2–4 nm with cations of methylene blue (MB+) in concentration 10-1–10-4 (νpaints/νCdS). Method involves double jet merging of 0.6–5 % solution of sodium sulphide and 0.8–7 % solution of cadmium bromide with melt of gelatin with producing of colloidal solution, containing colloidal quantum dots of CdS, solution is held at temperature of 4–10 °C, produced gelatine jelly is crushed to grain with size 5–10 mm, washed in distilled water at temperature from 7 to 13 °C for 30 minutes, decant excess water and granules are heated to temperature above 40°C. Nanomaterial is highly efficient generation of singlet oxygen and satisfactory parameters of cytotoxicity, testifies to its biocompatibility.
EFFECT: invention can be used in medicine and biology for photodynamic therapy of oncological and other human diseases.
2 cl, 6 dwg
Title | Year | Author | Number |
---|---|---|---|
METHOD FOR OBTAINING COMPOSITION FOR ANTIMICROBIAL COATING BASED ON ASSOCIATES OF SILVER SULFIDE NANOCRYSTALS WITH METHYLENE BLUE MOLECULES | 2020 |
|
RU2750232C1 |
METHOD OF OBTAINING SEMICONDUCTOR COLLOID QUANTUM POINTS OF CADMIUM SULPHIDE | 2013 |
|
RU2540385C2 |
PHOTOSENSIBILE ON THE BASIS OF SEMICONDUCTOR QUANTUM POINTS AND CHLORINE E6 | 2015 |
|
RU2629390C2 |
COMPLEX FOR THE DETECTION AND TARGETED DESTRUCTION OF CELLS | 2019 |
|
RU2743993C1 |
PHOTODYNAMIC THERAPY KIT | 2019 |
|
RU2740552C1 |
METHOD OF OBTAINING SEMICONDUCTOR COLLOIDAL SILVER SULFIDE QUANTUM DOTS | 2013 |
|
RU2538262C1 |
NANOCOMPOSITE PHOTOSENSITISER FOR METHOD OF PHOTODYNAMIC CELL EFFECT | 2006 |
|
RU2329061C1 |
METHOD OF PHOTO INACTIVATION OF BIRD INFLUENZA A VIRUS OF SUBTYPE H5N1 | 2007 |
|
RU2357770C1 |
PHOTOSENSITISERS FOR ANTIMICROBIAL PHOTODYNAMIC THERAPY | 2012 |
|
RU2497518C1 |
METHOD FOR PREVENTIVE TREATMENT OF CORONAVIRUS INFECTION | 2020 |
|
RU2777462C2 |
Authors
Dates
2017-01-10—Published
2014-10-10—Filed