BIOCOMPATIBLE NANOMATERIAL FOR PHOTOSENSITIVITY SINGLET OXYGEN AND METHOD FOR PRODUCTION THEREOF Russian patent published in 2017 - IPC A61K9/51 A61K47/42 C01G11/02 B82B3/00 

Abstract RU 2607579 C2

FIELD: medicine.

SUBSTANCE: group of inventions refers to medicine, in particular to oncology, and describes a biocompatible nanomaterial and method of its production. Proposed biocompatible nanomaterial is a hybrid associates of colloidal quantum dots CdS with average size of 2–4 nm with cations of methylene blue (MB+) in concentration 10-1–10-4 paintsCdS). Method involves double jet merging of 0.6–5 % solution of sodium sulphide and 0.8–7 % solution of cadmium bromide with melt of gelatin with producing of colloidal solution, containing colloidal quantum dots of CdS, solution is held at temperature of 4–10 °C, produced gelatine jelly is crushed to grain with size 5–10 mm, washed in distilled water at temperature from 7 to 13 °C for 30 minutes, decant excess water and granules are heated to temperature above 40°C. Nanomaterial is highly efficient generation of singlet oxygen and satisfactory parameters of cytotoxicity, testifies to its biocompatibility.

EFFECT: invention can be used in medicine and biology for photodynamic therapy of oncological and other human diseases.

2 cl, 6 dwg

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RU 2 607 579 C2

Authors

Ovchinnikov Oleg Vladimirovich

Smirnov Mikhail Sergeevich

Shatskikh Tamara Sergeevna

Shapiro Boris Issakovich

Popov Vasilij Nikolaevich

Bashmakov Viktor Yurevich

Khokhlov Vladimir Yurevich

Perepelitsa Aleksej Sergeevich

Dates

2017-01-10Published

2014-10-10Filed