MODIFIED PHOTOSENSITIZER BASED ON SELENIUM NANOPARTICLES AND HYDROPHILIC POLYMER Russian patent published in 2025 - IPC A61K33/00 A61K49/00 C08L1/02 

FIELD: biotechnology.

SUBSTANCE: invention relates to biotechnology, biochemistry, chemistry of high-molecular compounds and medicine. Disclosed is a method of modifying photosensitizers with selenium nanoparticles loaded into a cellulose polymer carrier. Selenium nanoparticles are carried out by means of a redox reaction in the presence of a cellulose polymer carrier to form a molecularly dispersed, time-stable solution at acidic pH of the medium (pH 3.2-3.6), with yield of 97±2 % for selenium. During the day, a dual nanosystem is formed – a cellulose polymer carrier/selenium nanoparticles, into which a photosensitizer is subsequently introduced, which leads to its binding and formation of a ternary hybrid nanosystem – cellulose polymer carrier/selenium nanoparticles/photosensitizer.

EFFECT: proposed approach enables to combine in one preparation various properties of both selenium nanoparticles and unmodified photosensitizer: antioxidant, anti-inflammatory, photophysical, anticancer properties.

1 cl, 6 dwg, 1 tbl, 3 ex