METHOD FOR OBTAINING COMPOSITION FOR ANTIMICROBIAL COATING BASED ON ASSOCIATES OF SILVER SULFIDE NANOCRYSTALS WITH METHYLENE BLUE MOLECULES Russian patent published in 2021 - IPC C30B29/46 C01G5/00 B82B3/00 B82Y5/00 B82Y40/00 C09D5/00 C09D5/14 C09D7/41 A61K31/10 

FIELD: antimicrobial agents.

SUBSTANCE: invention relates to the field of obtaining antimicrobial compositions and can be used as antimicrobial additives in paints and varnishes and for independent use in the disinfection of various surfaces. Method for obtaining a composition for an antimicrobial coating based on associates of silver sulfide nanocrystals (НК Ag₂S) with methylene blue molecules involves merging solutions of thioglycolic acid and silver nitrate at a temperature of 30°С with constant stirring, followed by drop-by-drop titration with an aqueous solution of NaOH, adding an aqueous solution of sodium sulfide with further mixing to form НК Ag₂S, adding acetone to the resulting mixture in a volume ratio of 1:1 and subsequent centrifugation, while using 0.027-0.03 Μ aqueous solution of thioglycolic acid, 0.0135-0.0154 Μ aqueous solution of silver nitrate, and constant mixing is carried out at a speed of 300-600 rpm while providing a molar ratio of 2:1, respectively, drip titration is carried out with 0.1 Μ aqueous solution of NaOH to pH 9, and then adding 0.02-0.023 Μ an aqueous solution of sodium sulfide with a temperature of 15 to 25C at a temperature of volume ratio of thioglycolic acid solution : silver nitrate solution : sodium sulfide solution - 2:2:1, respectively, further mixing is carried out for at least 20 minutes, and the resulting acetone solution with Ag2S NC is centrifuged at a speed of 5000 rpm for 30 minutes to precipitate Ag2S NC, which are then separated from the water-soluble reaction products by decanting, and 50% of the water-ethanol solution is added to the separated NK Ag2S precipitate in a volume equal to the sum of the volumes of mixed solutions of silver nitrate, thioglycolic acid and sodium sulfide, and a solution of methylene blue is added to the 96% ethanol in the molar ratio V_colorant/V_нк, making up 10^-1-10^-3.

EFFECT: resulting composition has a hydrophilic and experimentally confirmed antimicrobial effect.

1 cl, 3 dwg, 1 ex