IMIDAZOPYRIDINE DERIVATIVES AS MODULATORS OF TNF ACTIVITY Russian patent published in 2019 - IPC C07D471/04 A61K31/437 A61K31/444 A61P25/02 A61P25/28 A61P27/02 A61P29/00 A61P3/00 A61P35/00 A61P37/02 A61P43/00 A61P9/00

Abstract RU 2696275 C1

FIELD: chemistry.

SUBSTANCE: invention relates to organic chemistry and specifically to derivative of 3H-imidazo[4,5-c]pyridine of formula (IIA) or a pharmaceutically acceptable salt thereof, where E denotes -CH₂-; Q is -CH₂- or -CH₂O-; Z is hydrogen; or Z denotes phenyl or pyridinyl, any of these groups may optionally contain one substitute selected from C₁-C₆-alkoxy group and aminocarbonyl; R¹¹ denotes hydrogen; R¹⁵ denotes a halogen or difluoromethoxy group; and R¹⁶ denotes halogen. Invention also relates to a pharmaceutical composition based on a compound of formula (IIA), use thereof and a method of treating and/or preventing rheumatoid arthritis or Crohn's disease.

EFFECT: obtaining novel heterocyclic compounds having the properties of a TNFα activity modulator person.

5 cl, 5 ex

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RU 2 696 275 C1

Authors

Dzhekson Viktoriya Elizabet

Kroplin Boris

Porter Dzhon Robert

Dates

2019-08-01—Published

2014-12-08—Filed