BLOCK OF CCL18 SIGNALING THROUGH CCR6 AS THERAPEUTIC METHOD OF TREATING FIBROTIC DISEASES AND CANCER Russian patent published in 2017 - IPC A61K38/17 C07K14/47 A61P11/00 A61P35/00

Abstract RU 2609649 C2

FIELD: biotechnology.

SUBSTANCE: invention relates to biotechnology, namely to use of soluble polypeptide of CCR6 receptor in treating of interstitial pulmonary disease and/or lung cancer. Polypeptide containing CCLVYTSWQI, which consists of amino acid sequence, which has at least 90 % identity with respect to sequence according to SEQ ID NO: 9. Its fragment is also obtained, containing at least 12 amino acids of above sequence, including CCLVYTSWQI.

EFFECT: invention allows preparing polypeptide capable to inhibit CCL18 induced step-down regulation of CCR6 expression.

1 cl, 33 dwg, 17 ex

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RU 2 609 649 C2

Authors

Tsissel Gernot

Myuller-Kernkhajm Joakhim

Prasse Anti

Dates

2017-02-02—Published

2011-06-24—Filed