FIELD: chemistry.
SUBSTANCE: invention relates to organic chemistry, specifically to 2-(azaindol-2-yl)benzimidazole derivatives of formula (I) or a pharmaceutically acceptable salt thereof, where R1 is hydrogen; R2 is hydrogen, perhalomethylC0-5alkyl-O- or C1-6alkoxy; R3 is C1-6alkyl or C1-6alkoxyC1-6alkyl; R4 is C1-6alkyl, perhalomethylC1-6alkyl or unsubstituted C3cycloalkylC1-6alkyl; A is C-R5 or N; B is C-R6 or N; D is C-R7 or N; provided that one of A, B and D is N; R5, R6 and R8 are hydrogen; R7 is hydrogen, C1-6alkoxy or hydroxy; R9 is hydrogen or hydroxy; R10 is hydrogen or C1-6alkyl. Invention also relates to specific derivatives of 2-(azaindol-2-yl)benzimidazole and a pharmaceutical composition based on compound of formula (I).
EFFECT: novel derivatives of 2-(azaindol-2-yl)benzimidazole, useful as PAD4 inhibitors are obtained.
10 cl, 30 ex
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