ANTIMICROBIAL PEPTIDE VARIANTS AND POLYNUCLEOTIDES ENCODING SAME Russian patent published in 2017 - IPC C07K14/435 C12N15/12 A61K38/17 A61P31/00 

FIELD: biotechnology.

SUBSTANCE: present invention relates to variants of antimicrobial peptide, isolated polynucleotide, expression vector, host cell and method of producing such versions. Disclosed recovered version of the antimicrobial peptide, having an amino acid sequence SEQ ID NO: 2, where said variant has antimicrobial activity against gram-negative bacteria and contains amino acid sequence any of SEQ ID NO: 70, SEQ ID NO: 72, SEQ ID NO: 87, SEQ ID NO: 218, SEQ ID NO: 248, SEQ ID NO: 308, SEQ ID NO: 350, SEQ ID NO: 435 or SEQ ID NO: 450. Method of producing peptide involves cultivation of host cell containing polynucleotide, coding described peptide in conditions suitable for expression, and extraction of said peptide.

EFFECT: presented inventions can be used for treatment an infection caused by gram-negative bacteria.

8 cl, 8 tbl, 4 ex