FIELD: chemistry.
SUBSTANCE: invention relates to compounds of general formula 1a-f, where R1 – fragments (6,6-dimethylbicyclo[3.1.1]hept-2-en-2-yl)methyl (1a, 1b), (6,6-dimethylbicyclo[3.1.1]hept-2-en-2-yl)ethyl (1c, 1d), (2,2,3-trimethylcyclopent-3-en-1-yl)methyl (1e, 1f), R2 is residue of 1- or 2-adamantane (1a-f), and 2.
EFFECT: obtaining novel compounds which can be used in medicine as effective inhibitors of reproduction of viruses of the genus Orthopoxvirus, having high antiviral activity combined with low toxicity.
1 cl, 1 tbl, 8 ex
| Title | Year | Author | Number |
|---|---|---|---|
| AMIDES CONTAINING ADAMANTANE AND AROMATIC MOIETIES USED AS INHIBITORS OF ORTHOPOXVIRUS REPRODUCTION | 2021 |
|
RU2798665C2 |
| AGENT FOR INHIBITING HUMAN ENZYME TYROSYL-DNA-PHOSPHODIESTERASE 1 BASED ON PHENYLCOUMARINES, SENSITIZING TUMORS TO ANTITUMOUR AGENTS | 2019 |
|
RU2724878C1 |
| ADAMANTYL-CONTAINING DERIVATIVES OF 1,2,4-TRIAZOLE AND 1,3,4-THIADIAZOLE HAVING MONOTERPENOID FRAGMENTS USED AS INHIBITORS OF THE ENZYME TYROSYL-DNA PHOSPHODIESTERASE 1 | 2020 |
|
RU2761880C1 |
| MEANS FOR HUMAN TYROSYL-DNA-PHOSPHODIESTERASE 1 ENZYME INHIBITION | 2015 |
|
RU2612875C1 |
| CHIRAL MYRTANYL SULPHONAMIDES | 2019 |
|
RU2725878C1 |
| N-HETEROCYCLIC BORNYL AMINE DERIVATIVES AS ORTHOPOXVIRUS INHIBITORS | 2018 |
|
RU2687254C1 |
| DERIVATIVES OF 7-HYDROXYCOUMARIN CONTAINING MONOTERPENOID RESIDUES AS INHIBITORS OF RESPIRATORY SYNCYTIAL VIRUS (RSV) REPRODUCTION | 2022 |
|
RU2787352C1 |
| CHIRAL MONOTERPENE SULFINAMIDES | 2017 |
|
RU2646959C1 |
| 1-HYDROXY- AND 1-METHOXY-2-(4-NITROPHENYL)IMIDAZOLE DERIVATIVES WITH ANTIVIRAL ACTIVITY AGAINST ORTHOPOXVIRUSES | 2022 |
|
RU2794763C1 |
| N-BORNIL- AND N-PHENCHYLCARBOXAMIDES USED AS ORTHOPOXVIRUS REPLICATION INHIBITORS | 2022 |
|
RU2800448C1 |
