FIELD: medicine.
SUBSTANCE: group of the inventions relates to field of biotechnology. Claimed is L-lysine-producing bacterium of genus Corynebacterium, modified in such a way that amino acid substitution H461Q is contained in amino acid sequence of product of mutant gene fusA. Claimed is L-lysine-producing bacterium of genus Brevibacterium, modified in such a way that amino acid substitution H461Q is contained in amino acid sequence of product of mutant gene fusA. Claimed is method for obtaining L-lysine, which includes cultivation of any of said modified bacteria.
EFFECT: group of inventions makes it possible to increase level of L-lysine production in said strains-producents by not less than 9% in comparison with parential strains-producents of L-lysine.
3 cl, 1 tbl, 3 ex
| Title | Year | Author | Number |
|---|---|---|---|
| L-LYSIN-PRODUCING CORYNEFORMIC BACTERIUM WITH INACTIVE LTBR GENOME AND METHOD FOR OBTAINING OF L-LYSIN USING THIS BACTERIUM | 2016 |
|
RU2639247C1 |
| BACTERIUM CORYNEBACTERIUM GLUTAMICUM WITH INCREASED ABILITY TO PRODUCE L-VALINE AND METHOD FOR PRODUCING L-VALINE USING THIS BACTERIUM | 2020 |
|
RU2753996C1 |
| L-LYSINE PRODUCING Corynebacterium glutamicum OR Brevibacterium flavum BACTERIA, RESISTANT TO FUSIDIC ACID, AND METHOD FOR MICROBIOLOGICAL SYNTHESIS OF L-LYSINE USING SAME | 2013 |
|
RU2549690C1 |
| METHOD OF PREPARING L-LYSINE (VARIANTS) AND RECOMBINANT DNA USED FOR ITS REALIZATION (VARIANTS) | 1996 |
|
RU2197528C2 |
| L-AMINO ACID PRODUCING CORYNEFORMOUS BACTERIUM AND METHOD FOR OBTAINING L-AMINO ACID | 2004 |
|
RU2333247C2 |
| METHOD TO PRODUCE L-AMINO ACID OF GLUTAMATE FAMILY USING CORYNEFORMIC BACTERIUM | 2011 |
|
RU2496867C2 |
| CORYNEBACTERIUM GENUS MICROORGANISM WITH IMPROVED ABILITY TO PRODUCE L-LYSINE AND METHOD FOR PRODUCING L-LYSINE USING SAME | 2014 |
|
RU2651505C1 |
| MODIFIED PHOSPHOENOLPYRUVATE CARBOXYLASE, DNA FRAGMENT, STRAIN ESCHERICHIA COLI, RECOMBINANT DNA, METHOD OF PREPARING AMINO ACID (VARIANTS), METHOD OF ESCHERICHIA COLI CELLS SELECTION, METHOD OF PREPARING MODIFIED PHOSPHOENOLPYRUVATE CARBOXYLASE, METHOD OF PREPARING DNA FRAGMENT AND METHOD OF MICROORGANISM PREPARING | 1994 |
|
RU2133772C1 |
| MICROORGANISM WHICH POSSESS PRODUCTIVITY OF L-LYSINE, AND METHOD OF PRODUCING L-LYSINE USING THIS MICROORGANISM | 2016 |
|
RU2683551C1 |
| METHOD OF BUILDING (2S,3R,4S)-4-HYDROXY-L-ISOLEUCINE PRODUCING BACTERIA, (2S, 3R, 4S)-4-HYDROXY-L-ISOLEUCINE PRODUCING BACTERIA AND METHOD OF PRODUCING (2S, 3R, 4S)-HYDROXY-L-ISOLEUCINE OR SALT THEREOF | 2007 |
|
RU2395580C2 |
