AMINOINDANE COMPOUNDS AND USE THEREOF IN TREATING PAIN Russian patent published in 2017 - IPC C07D207/09 C07D211/26 C07D401/12 C07D405/12 C07D417/12 C07D471/10 C07D498/10 A61K31/452 A61P23/02 A61P29/02 

FIELD: chemistry.

SUBSTANCE: invention relates to novel aminoindane compounds of formulae (I) or (II): , where: A is phenyl or a monocyclic aromatic 5- or 6-member ring containing 1 or 2 heteroatoms selected from N and S; R¹ and R⁴ are independently C₁-C₆ alkyl or CH₂CH₂OH; or R¹ and R⁴ are combined to form a 4-6-membered carbocyclic or saturated 5- or 6-member monocyclic group containing one additional ring heteroatom, such as O; R² is independently selected from a group consisting of halogen; R³ is independently selected from a group consisting of halogen and C₁-C-₆ alkyl; or q equals 2, and two R³ groups are bonded to form a saturated 5- or 6-member monocyclic group containing 1–2 oxygen atoms; m is ranges from 1 to 3; n ranges from 1 to 3; p ranges from 0 to 2; q ranges from 0 to 2; and X^- is a halogen, trifluoroacetate, sulphate, etc, as well as methods of producing and using said compounds. Methods involve administering a compound of formula (I) or (II) and a TRPV1 receptor activator.

EFFECT: said compounds can find application in treating pain and/or itching.

14 cl, 8 tbl, 11 dwg, 59 ex