METHOD OF DETECTING MUTATIONS IN COMPLEX DNA MIXTURES Russian patent published in 2017 - IPC C12Q1/68 C12N15/11

Abstract RU 2613489 C2

FIELD: biochemistry.

SUBSTANCE: in some applications non-mutant DNA is present in the sample in thousandfold excess. Method involves molecular bar-coding of DNA molecules, their amplification, sequencing of new generation and analysis of sequence data.

EFFECT: present invention is aimed at methods for detection in sample of mutations in DNA, where mutant DNA is present on the background of a non-mutant DNA.

3 cl, 5 dwg, 5 tbl, 4 ex

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RU 2 613 489 C2

Authors

Dates

2017-03-16—Published

2014-09-17—Filed