METHOD FOR QUANTITATIVE DETERMINATION OF DIBENZOTIOXANTHENE DERIVATIVES (TIXOL GROUP) Russian patent published in 2017 - IPC G01N21/78 G01N33/15 

FIELD: chemistry.

SUBSTANCE: invention refers to pharmaceutical industry. Exact portions of hydrochloride chlorprothixene 0.010 g, zuclopenthixol 0.025 g and flupenthixol 0.005 g powders are placed in 50 ml flasks, first, dissolved in 15-20 ml of 0.1 n. KOH, kept at the room temperature until complete dissolution, and then adjusted to the flask volume mark with the same KOH solution, then 3.0, 4.0, 5.0, 6.0, 7.0 ml of the prepared flupenthixol, and zuclopenthixol solutions, 3.0, 3.5, 4.0, 4.5, 5.0 ml of chlorprothixene solution are exactly metered into 20 ml volumetric flasks, 0.5 ml of 5% sodium sulfite solution, 1.5 ml of 0.1 m KOH solution are added successively, shaken at the room temperature for 5 minutes, then 0.5 ml of 3% sodium nitroprusside alkali solution, 1 ml of 0.1 m KOH and 1.0 ml of ammonia buffer solution with pH of 10 are added, kept for 1 minute, a bright red colour appears, stable for 2 h, solution volumes are adjusted to the mark with buffer solution, and optical density of absorbtion is measured for the coloured solution by means of a photoelectric colorimeter at wave length of 490 nm and absorbing layer thickness of 10 mm.

EFFECT: pharmaceutical analysis applied for quantitative determination of hydrochloride chlorprothixene, zuclopenthixol and flupenthixol content in substances.

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