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(19)

(11)

2 648 448

(13)

(51)

IPC

A61K9/00(2006-01-01)

A61K9/14(2006-01-01)

A61K9/20(2006-01-01)

A61K31/498(2006-01-01)

A61K47/32(2006-01-01)

A61K47/38(2006-01-01)

A61P35/00(2006-01-01)

(21) (22)

Application

2014119283, 2012-10-12

(24)

Start date

2012-10-12

(22)

Actual filing date

2012-10-12

(45)

Published

2018-03-26

(72)

Inventor

Fraj Devid ShenkLindemann Kristofer M.Prej MajklBlum Kori DzhejKrejg Kristofer DonovanDyuboz Devon BrevarGotshi DzhefSmiti Den

(73)

Holder

Errej Biofarma Ink.

SOLID DISPERSION Russian patent published in 2018 - IPC A61K9/00 A61K9/14 A61K9/20 A61K31/498 A61K47/32 A61K47/38 A61P35/00

Abstract RU 2648448 C2

FIELD: medicine.

SUBSTANCE: invention relates to medicine, namely to solid dispersion capable of inhibiting ErbB2, pharmaceutical composition containing this solid dispersion, method of treating cancer, and application of composition for treating cancer. Solid dispersion contains amorphous N4-(4-([1,2,4]triazolo[1,5-a]pyridin-7-yloxy)-3-methylphenyl)-N6-(4,4-dimethyl-4,5-dihydrooxazol-2-yl)quinazoline-4,6-diamine and a dispersion polymer.

EFFECT: implementation of the invention will increase pharmacokinetics of the active substance.

51 cl, 6 tbl, 18 ex, 13 dwg

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RU 2 648 448 C2

Authors

Fraj Devid Shenk

Lindemann Kristofer M.

Prej Majkl

Blum Kori Dzhej

Krejg Kristofer Donovan

Dyuboz Devon Brevar

Gotshi Dzhef

Smiti Den

Dates

2018-03-26—Published

2012-10-12—Filed