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IPC

A61K31/16(2006-01-01)

A61P31/10(2006-01-01)

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Application

2016118952, 2016-05-16

(24)

Start date

2016-05-16

(22)

Actual filing date

2016-05-16

(45)

Published

2017-04-13

(72)

Inventor

Yarovaya Olga IvanovnaShtro Anna AndreevnaOrshanskaya Yana RafaelevnaZarubaev Vladimir ViktorovichKhazanov Veniamin AbramovichSalakhutdinov Nariman Faridovich

(73)

Holder

Federalnoe Gosudarstvennoe Byudzhetnoe Uchrezhdenie Nauki Novosibirskij Institut Organicheskoj Khimii Im. N.N. Vorozhtsova Sibirskogo Otdeleniya Rossijskoj Akademii Nauk So Ran)Federalnoe Gosudarstvennoe Byudzhetnoe Uchrezhdenie Institut Grippa" Ministerstva Zdravookhraneniya Rossijskoj Federatsii Grippa" Minzdrava Rossii)Obshchestvo S Ogranichennoj Otvetstvennostyu

(1S,3aR,4R,7aS)-N-(2,2,4,7a-TETRAMETHYLOCTAHYDRO-1,4-ETHANOINDENE-3a-YL)-ACETAMIDE APPLICATION AS A INFLUENZA VIRUS REPRODUCTION INHIBITOR Russian patent published in 2017 - IPC A61K31/16 A61P31/10

Abstract RU 2616255 C1

FIELD: medicine.

SUBSTANCE: invention relates to medicine and concerns (1S, 3aR, 4R, 7aS)-N-(2,2,4,7a-tetramethyloctahydro-1,4-ethanoindene-3a-yl)-acetamide of formula I

including its configurational isomers, including optically active forms. Application of the said compound as an influenza virus reproduction inhibitor is proposed. Formula I compound inhibits the replication of rimantadine-resistant influenza virus A/California/07/09 (H1N1)pdm09 and A/Puerto Rico/ 8/34 (H1N1); its chemotherapeutic index is much higher than that of the reference drugs.

EFFECT: increased efficiency of influenza virus replication suppression and expansion of the of influenza virus reproduction inhibitors range to overcome drug resistance of modern viral strains.

1 tbl, 4 ex

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RU 2 616 255 C1

Authors

Yarovaya Olga Ivanovna

Shtro Anna Andreevna

Orshanskaya Yana Rafaelevna

Zarubaev Vladimir Viktorovich

Khazanov Veniamin Abramovich

Salakhutdinov Nariman Faridovich

Dates

2017-04-13—Published

2016-05-16—Filed