FIELD: medicine.
SUBSTANCE: invention relates to medicine and concerns (1S, 3aR, 4R, 7aS)-N-(2,2,4,7a-tetramethyloctahydro-1,4-ethanoindene-3a-yl)-acetamide of formula I
,
including its configurational isomers, including optically active forms. Application of the said compound as an influenza virus reproduction inhibitor is proposed. Formula I compound inhibits the replication of rimantadine-resistant influenza virus A/California/07/09 (H1N1)pdm09 and A/Puerto Rico/ 8/34 (H1N1); its chemotherapeutic index is much higher than that of the reference drugs.
EFFECT: increased efficiency of influenza virus replication suppression and expansion of the of influenza virus reproduction inhibitors range to overcome drug resistance of modern viral strains.
1 tbl, 4 ex
Title | Year | Author | Number |
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USING 1,7,7-TRIMETHYLBICYCLO[2,2,1]HEPTAN-2-YLIDENE-AMINOETHANOL AS INFLUENZA VIRUS REPRODUCTION INHIBITOR | 2013 |
|
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IMINE COMPOUNDS OF CAMPHOR - EFFECTIVE INHIBITORS OF REPRODUCTION OF FLU VIRUS (A/California/07/09 (H1N1)pdm09 STRAIN) | 2014 |
|
RU2554934C1 |
IMINE DERIVATIVES OF CAMPHOR, CONTAINING AROMATIC OR HETEROAROMATIC FRAGMENT - INHIBITORS OF REPRODUCTION OF FLU VIRUS (STRAIN A/CALIFORNIA/07/09(H1N1)pdm09) | 2015 |
|
RU2607451C1 |
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|
RU2664331C1 |
SYMMETRIC DIIMINES BASED ON CAMPHOR - INHIBITORS OF REPRODUCTION OF INFLUENZA VIRUS (STRAIN A/California/07/09 (H1N1)pdm09) | 2013 |
|
RU2520967C1 |
1-[ω-ARYLOXYALKYL(BENZYL)]-SUBSTITUTED 2-AMINOBENZIMIDAZOLES, HAVING ACTIVITY ON INFLUENZA VIRUS | 2012 |
|
RU2570906C2 |
APPLICATION OF ALIPHATIC IMINO-DERIVATIVES OF CAMPFOR AS EFFECTIVE INHIBITORS OF REPRODUCTION OF INFLUENZA VIRUS STRAIN A/CALIFORNIA/07/09 (H1N1) PDM09 AND A/PUERTO RICO/8/34 (H1N1) | 2016 |
|
RU2651754C1 |
PEPTIDE-BASED COMPOSITION SUPPRESSING REPLICATION OF INFLUENZA A VIRUS | 2018 |
|
RU2695336C1 |
USNIC ACID AND ITS OXIDATED DERIVATIVE AS INFLUENZA VIRUS REPRODUCTION INHIBITORS | 2011 |
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RU2464033C1 |
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|
RU2492178C1 |
Authors
Dates
2017-04-13—Published
2016-05-16—Filed