FIELD: medicine.
SUBSTANCE: invention relates to the field of medicine and pharmaceutics. Use of imino-derivatives of camphor of general formula (I), where n=1, 2, 3, 4, 5, as inhibitors of reproduction of the influenza virus strain A/California/07/09 (H1N1) pdm09 and A/Puerto Rico/8/34 (H1N1). 
.
EFFECT: compounds show a pronounced antiviral activity along with low toxicity – the chemotherapeutic index of the compounds (1a-e) is much higher than that of the reference drugs.
1 cl, 1 tbl, 5 ex
| Title | Year | Author | Number |
|---|---|---|---|
| HYDROCHLORIDE 1,7,7-TRIMETHYLBICYCLO[2.2.1]HEPTAN-2-YL 3-(PIPERIDIN-1-YL)PROPIONATE USED AS AN EBOLA VIRUS INHIBITOR | 2019 |
|
RU2697716C1 |
| IMINE COMPOUNDS OF CAMPHOR - EFFECTIVE INHIBITORS OF REPRODUCTION OF FLU VIRUS (A/California/07/09 (H1N1)pdm09 STRAIN) | 2014 |
|
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| 3-N-SUBSTITUTED BORNYL PROPIONATES USED AS MARBURG VIRUS INHIBITORS | 2017 |
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| IMINE DERIVATIVES OF CAMPHOR, CONTAINING AROMATIC OR HETEROAROMATIC FRAGMENT - INHIBITORS OF REPRODUCTION OF FLU VIRUS (STRAIN A/CALIFORNIA/07/09(H1N1)pdm09) | 2015 |
|
RU2607451C1 |
| N-HETEROCYCLIC BORNYL AMINE DERIVATIVES AS ORTHOPOXVIRUS INHIBITORS | 2018 |
|
RU2687254C1 |
| SYMMETRIC DIIMINES BASED ON CAMPHOR - INHIBITORS OF REPRODUCTION OF INFLUENZA VIRUS (STRAIN A/California/07/09 (H1N1)pdm09) | 2013 |
|
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| O-ACYLAMIDOXIMES AND 1,2,4-OXADIAZOLES CONTAINING A FRAGMENT OF BICYCLO[2.2.1]HEPTANONE-2 AS INHIBITORS OF THE REPRODUCTION OF PHYLOGENETICALLY DIFFERENT INFLUENZA A VIRUSES: STRAINS A/PUERTO RICO/8/34 (H1N1), A/ANHUI/1/2013 (H7N9) | 2022 |
|
RU2798171C1 |
| 1-[ω-ARYLOXYALKYL(BENZYL)]-SUBSTITUTED 2-AMINOBENZIMIDAZOLES, HAVING ACTIVITY ON INFLUENZA VIRUS | 2012 |
|
RU2570906C2 |
| 6,13,13-TRIMETHYL-6,8,9,12-TETRAHYDRO-6,9-METHANOSEPINO[2,1-B]HINAZOLIN-10(7H)-ONE AS THE INHIBITOR OF INFLUENZA VIRUSES | 2017 |
|
RU2664331C1 |
| AGENT REPRESENTING GLYCYRRHIZIC ACID AMIDE WITH 5-AMINOURACIL SHOWING ANTIVIRAL ACTIVITY ON A/H1N1 INFLUENZA VIRUS | 2014 |
|
RU2568849C9 |
