PAZOPANIB COMPOSITION Russian patent published in 2017 - IPC A61K31/505 A61K31/506 A61P35/00 

FIELD: medicine, pharmacy.

SUBSTANCE: granular composition of 5-[[4-[2,3-dimethyl-2H-indazol-6-yl)methylamino]-2-pyrimidinyl]amino]-2-methylbenzenesulfonamide or pharmaceutically acceptable salt thereof, possessing VEGF-inhibitory activity is prepared to be recovered by an aqueous carrier, and the corresponding oral suspension. In addition, the suspension obtained is stable during storage. The said technical result is achieved by guar gum application as a thickener and hypromellose or polyvinylpyrrolidone appliaction as a suspending agent.

EFFECT: invention provides a pazopanib composition for suspension with thixotropic properties that allow to reduce the viscosity of the suspension while shaking to facilitate pouring or dispensing; wherein suspension viscosity increases while the container remains fixed, which allows the particles to remain in suspension without settling and aggregation.

18 cl, 3 ex, 4 tabl, 2 dwg