FIELD: pharmacology.
SUBSTANCE: invention relates to application of adamantane-containing indoles and their hydrochlorides of general formula
where R1, R2, R3, R4 may be the same or different and independently represent H, F, Cl, Br, (C1-C6) alkyl, (C1-C6) alkoxy; R5, R6 may be the same or different and independently represent H, (C1-C6) alkyl, ONO2; X represents CH2CH(OH)CH2 or CH2CH2C(O); Z=no, Cl; R7, R8, R9, R10 may be the same or different and independently represent H, F, Cl, Br, (C1-C6) alkyl, (C1-C6) alkoxy; R11, R12, R13, R14, R15, R16, R17, R18 may be the same or different and independently represent H, (C1-C6) alkyl, as a cholinesterase inhibitors and NMDA receptors blockers, and can be used as new drugs that interact with several targets responsible for improval of memory and cognitive functions, weakening of which has various origin, including dementias of various origins, especially due to neurodegenerative diseases, such as Alzheimer's disease.
EFFECT: increased compound application effeciency.
15 cl, 1 dwg, 1 tbl, 3 ex
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