FIELD: chemistry; pharmacology.
SUBSTANCE: invention relates to use of adamantane-containing indole derivatives and their hydrochlorides of general formula 1, where R1, R2, R3, R4 can be identical or different and independently represent H, F, Cl, Br, (C1-C6)alkyl, (C1-C6)alkoxy; R5, R6 can be identical or different and independently represent H, (C1-C6)alkyl, ONO2; X is CH2CH(OH)CH2 or CH2CH2C(O); Z = no, Cl; as cytoprotectors in treating and preventing of diseases associated with increase in cytosolic calcium concentration.
EFFECT: treatment and prevention of diseases associated with increase in cytosolic calcium concentration.
31 cl, 9 dwg, 8 ex
,
| Title |
Year |
Author |
Number |
| APPLICATION OF ADAMANTANE INDOLE AND THEIR HYDROCHLORIDES AS CHOLINESTERASE INHIBITORS AND NMDA-RECEPTORS BLOCKERS |
2016 |
- Bachurin Sergej Olegovich
- Makhaeva Galina Fajvelevna
- Grigorev Vladimir Viktorovich
- Boltneva Natalya Pavlovna
- Kovaleva Nadezhda Vladimirovna
- Sokolov Vladimir Borisovich
- Aksinenko Aleksej Yurevich
|
RU2621348C1 |
| ADAMANTANE-CONTAINING INDOLES AND THEIR HYDROCHLORIDES WITH MICROTUBULES STABILIZING PROPERTY, METHODS OF THEIR PRODUCTION, PHARMACOLOGICAL AGENT BASED THEREON AND METHOD OF TREATING AND PREVENTING DISEASES ASSOCIATED WITH MICROTUBULE SYSTEM DISORDERS |
2015 |
- Bachurin Sergej Olegovich
- Sokolov Vladimir Borisovich
- Aksinenko Aleksej Yurevich
- Epishina Tatyana Andreevna
- Goreva Tatyana Vladimirovna
- Shevtsova Elena Feofanovna
- Shevtsov Pavel Nikolaevich
|
RU2608631C1 |
| METHOD (VERSIONS) AND PREPARATION FOR MODIFICATION OF EATING BEHAVIOUR |
2002 |
- Batler Ehndrju
- Blum Stivn Robert
- Behtterkhehm Rechel Luiza
- Gatej Mokhammad Ali
- Kaulej Majkl
- Koun Rodzher
- Lou Malkem
- Smoll Kehrolajn Dzhejn
|
RU2519748C2 |
| METHOD OF TREATMENT OF STATE WHERE 5HT-LIKE AGONIST, DERIVATIVE OF TETRAHYDROCARBAZOLE IS REQUIRED, METHOD OF ITS SYNTHESIS, PHARMACEUTICAL COMPOSITION SHOWING ACTIVITY OF AGONIST OF 5HT-LIKE RECEPTORS |
1992 |
- Frehnsis Dehvid King
- Larami Mehri Gehster
- Al'Berto Dzhulio Kaumann
- Rodni Kristofer Jang
|
RU2137474C1 |
| DERIVATIVES OF TETRAHYDROCARBAZOLE, METHOD FOR PREPARING TETRAHYDROCARBAZOLE (VARIANTS), THEIR USING (VARIANTS) AND PHARMACEUTICAL COMPOSITION POSSESSING ACTIVITY OF ANTAGONIST OF GONADOTROPIN-RELEASING HORMONE (VARIANTS) |
2002 |
- Koppits Markus
- Mun Khans Peter
- Paulini Klaus
- Khess-Shtump Khol'Ger
- Shou Ken
|
RU2319692C2 |
| METHOD OF PRODUCING HYDROCHLORIDES OF AMINE-DERIVATIVES OF ADAMANTANE |
2010 |
- Butov Gennadij Mikhajlovich
- Pershin Valerij Vasil'Evich
- Burmistrov Vladimir Vladimirovich
|
RU2440971C1 |
| METHOD FOR PRODUCTION OF PYRLINDONE HYDROCHLORIDE |
2000 |
- Ferrari Massimo
- Getstsi Marchello
- Belotti Paolo
- Dzinetti Fabritsio
|
RU2249592C2 |
| PHENOTHIAZINE-CONTAINING 1,2,3,4-TETRAHYDROPYRIDO[4,3-b]INDOLE DERIVATIVES AS AGENT FOR REDUCING UNCONTROLLED PROTEIN AGGREGATION IN NERVOUS SYSTEM, METHODS FOR PRODUCTION THEREOF, PHARMACOLOGICAL AGENT BASED THEREON AND METHOD OF REDUCING UNCONTROLLED PROTEIN AGGREGATION IN NERVOUS SYSTEM |
2013 |
- Bachurin Sergej Olegovich
- Sokolov Vladimir Borisovich
- Aksinenko Aleksej Jur'Evich
- Makhaeva Galina Fajvelevna
- Grigor'Ev Vladimir Viktorovich
- Ninkina Natal'Ja Nikolaevna
- Kukharskij Mikhail Sergeevich
|
RU2529899C1 |
| SUBSTITUTED DERIVATIVES OF CYCLOHEXAN-1,4-DIAMINE, METHOD FOR THEIR PREPARING AND DRUG |
2002 |
- Zundermann Bernd
- Khennis Khagen-Khajnrikh
- Ehngl'Berger Verner
- Kegel' Babetta-Ivonna
|
RU2321579C2 |
| SELECTIVE HISTAMINE H4 RECEPTOR ANTAGONISTS FOR TREATING VESTIBULAR DISORDERS |
2009 |
- Desmadril Zhil
- Shaber Kristyan
|
RU2589846C2 |
