FIELD: chemistry; medicine.
SUBSTANCE: invention relates to novel adamantane-containing indoles and their hydrochlorides of general formula 1, in which R1, R2, R3, R4 can be identical or different and independently represent H, F, Cl, Br, (C1-C6)alkyl, (C1-C6)alkoxy; R5, R6 can be identical or different and independently represent H, (C1-C6)alkyl, ONO2; X is CH2CH(OH)CH2 or CH2CH2C(O); Z = no, Cl; R7, R8, R9, R10 can be identical or different and independently represent H, F, Cl, Br, (C1-C6)alkyl, (C1-C6)alkoxy; R11, R12, R13, R14, R15, R16, R17, R18 can be identical or different and independently represents H, (C1-C6)alkyl.
EFFECT: compounds possess microtubules stabilization property and may be used for treating or preventing diseases related to disturbed microtubule system, for example, such as hyperproliferative manifestations and neurodegenerative disorders.
22 cl, 7 dwg, 54 ex
,
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