FIELD: biotechnology.
SUBSTANCE: recombinant strain of VACΔ6 vaccinia virus with broken genes C3L, N1L, J2R, A35R, A56R, B8R on the basis of cloned vaccinia virus (L-IVP strain). The proposed strain is deposited in State Collection of causative agents of viral infections, rickettsiosis of the SBSI of the SSC VB Vector with registration No. V-696 and is designed to produce a bladeless, attenuated live culture vaccine against the natural smallpox and other orthopoxviruses with enhanced immunogenic and protective activity.
EFFECT: proposed recombinant strain can be used in medicine to produce a vaccine against natural smallpox and other human orthopoxviral infections.
7 dwg, 2 tbl, 13 ex
| Title | Year | Author | Number |
|---|---|---|---|
| RECOMBINANT STRAIN L-IVP 1421ABJCN POX VIRUS VIRULENCE GENES WITH BROKEN A56R, B8R, J2R, C3L, N1L FOR PRODUCING LIVE CULTURE OF ATTENUATED SMALLPOX VACCINE AND OTHER ORTHOPOXVIRUSES, PATHOGENIC FOR HUMANS | 2015 |
|
RU2588388C1 |
| LIVE ATTENUATED CULTURE VACCINE FOR PREVENTION OF SMALLPOX AND OTHER ORTHOPOXVIRUS INFECTIONS BASED ON SMALLPOX VACCINE VIRUS AND METHODS FOR ITS PREPARATION AND APPLICATION | 2022 |
|
RU2781070C1 |
| RECOMBINANT STRAIN VV-GMCSF-Lact OF VACCINIA VIRUS, HAVING ONCOLYTIC ACTIVITY AND PRODUCING GRANULOCYTIC-MACROPHAGAL COLONY-STIMULATING FACTOR AND ONCOTOXIC LACTAPTIN PROTEIN | 2015 |
|
RU2604187C1 |
| RECOMBINANT VARIOLOVACCINE VIRUS STRAIN VV-NS1-dGF PRODUCING NS1 PARVOVIRUS H-1 PROTEIN AND HAVING ONCOLYTIC ACTIVITY ON HUMAN GLIOBLASTOMA | 2018 |
|
RU2692628C1 |
| RECOMBINANT STRAIN OF VV-GMCSF-S-Lact VACCINIA VIRUS, WITH ONCOLYTIC ACTIVITY, PRODUCING GRANULOCYTOR-MACROPHAGAL COLONY-STIMULATING HUMAN FACTOR AND SECRETED FORM OF LACTAPTIN ONCOTOXIC PROTEIN | 2016 |
|
RU2621861C1 |
| RECOMBINANT STRAIN VV-GMCSF-S1/3 OF VACCINIA VIRUS, PRODUCING SECRETED GRANULOCYTE-MACROPHAGE COLONY-STIMULATING HUMAN FACTOR | 2013 |
|
RU2565544C2 |
| RECOMBINANT OF VV-GMCSF / LACT-DGF VIRUS OF OSVOVICINE, OF ONLY-COLIC ACTIVITY AND PRODUCING SECRETABLE CHIMERIC WHITE, CONTAINING FROM GRANULOCYTE-MACROPHAGAL COLONISTIMULATING HUMAN FACTOR AND ONCOTOXIC PROTEIN OF LACTAPTIN | 2016 |
|
RU2630672C1 |
| RECOMBINANT STRAIN VV-mNIS-NS1 OF VACCINIA VIRUS PRODUCING mNIS SODIUM IODIDE SYMPORTER OF MICE AND NS1 PROTEIN OF RAT PARVOVIRUS H-1 FOR MALIGNANT TUMOUR THERANOSTICS | 2023 |
|
RU2819082C1 |
| ANTI-TUMOUR AGENT BASED ON RECOMBINANT VACCINIA VIRUS STRAIN AND METHOD FOR PRODUCTION THEREOF | 2019 |
|
RU2730657C1 |
| RECOMBINANT PLASMID DNA pGEM-Puro-DS-Apo COMPRISING SYNTHETIC APOPTIN GENE FLANKED BY SEQUENCES OF VACCINIA VIRUS GENOME OF ISLAND C10L-C12L, AND RECOMBINANT STRAIN VVdGF-ApoS24/2 OF VACCINIA VIRUS PRODUCING APOPTIN | 2012 |
|
RU2492238C1 |
