HYPOALLERGENIC VARIANTS OF MAL D 1, MAIN MALUS DOMECTICA ALLERGEN Russian patent published in 2017 - IPC C07K14/415 C07K19/00 C12N15/62 C12N15/63 A61K39/36 A61P37/08 

FIELD: biotechnology.

SUBSTANCE: aprotein is produced. It is a hypoallergenic mutant of the main Malus domectica Mal d 1 allergen TCD having SEQ ID NO: 1 for the use in immune therapy of patients allergic to Malus domectica and/or Betula verrucosa pollen. The resulting protein has an amino acid sequence. When the SEQ ID NO: 1 is aligned in it, there are either two substitutions, including the Asp residue substitution at position 25 and the Asn residue substitution at position 78, or one Asn residue substitution at position 78 of the sequence SEQ ID NO: 1, where these residues of Asp at position 25 and/or of Asn at position 78 are substituted by Ala residue. The invention allows producing a hypoallergenic mutant of the main Malus domectica Mal d 1 allergen which shows a reduced IgE reactivity compared to the specified Mal d 1 allergen with SEQ ID NO: 1.

EFFECT: possibility of using in medicine for the treatment of allergic diseases.

14 cl, 15 dwg, 3 tbl, 13 ex