FIELD: medicine; neurology.
SUBSTANCE: invention can be used for disintegration of amyloid fibrils from TTR (transthyretine). Method involves administering to a subject in need thereof a therapeutically effective amount of at least one catechol-O-methyltransferase (COMT) inhibitor of formula I or its pharmaceutically acceptable salt
where R is selected from a group consisting of -C(O)-PhCH3, -CH=C(CN)-C(O)-NEt2 and -CH=C(C(O)CH3)2.
EFFECT: use of the invention enables to achieve considerable disintegration and high inhibitory activity on formation of amyloid fibrils from TTR.
17 cl, 6 tbl, 6 ex, 4 dwg
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