METHOD TO OBTAIN OPTIMIZED SOLID GENE-ACTIVATED MATERIAL, METHOD TO OBTAIN SOLID CARRIER MATRIX, OPTIMIZED SOLID GENE-ACTIVATED MATERIAL FOR TISSUE REGENERATION Russian patent published in 2017 - IPC C12Q1/68 A61K48/00 

FIELD: biotechnology.

SUBSTANCE: method for production of an optimized solid gene-activated material is described, comprising creation of a carrier matrix that binds at least one nucleic acid molecule, followed by placing at least one additional nucleic acid molecule on its surface by any physical method allowing such placement without chemical bond formation between the said carrier matrix and the additional nucleic acid. Also a process for preparation of a solid carrier matrix used in the method described and intended for binding of at least one nucleic acid molecule, comprising introduction of any complexing agent into the solid matrix carrier at the stage of its synthesis by treating the initial material with a solution containing a metal-complexing agent salt capable of binding of at least one nucleic acid molecule is provided. Products obtained by these methods are presented as well.

EFFECT: invention allows to receive optimized osteoplastic materials having an accurate dose of nucleic acids, more efficient dynamics of gene structures release from carrier matrix structure and increased level of recipient bed cells transfection by the biologically active substance.

5 cl, 5 dwg, 2 tbl, 2 ex