FIELD: biotechnology.
SUBSTANCE: carrier is proposed for targeted delivery of nucleic acids to cells expressing the receptor CXCR4, which consists of a sequence-ligand to the receptor CXCR4 with the amino acid sequence KPVSLSYRSPSRFFESH, the linker part of two molecules of ε-aminohexanoic acid linking the sequence-ligand to the sequence for compaction of nucleic acids, the sequence providing compaction of nucleic acids and the complex output from endosomes CHRRRRRRHC.
EFFECT: invention can be used for targeted delivery of genetic structures into cells with the receptor CXCR4 on the surfaces, such as malignant tumour and stem cells, in order to correct genetic defects, influence on processes of implementation of the genetic information and prevention of diseases.
3 cl, 7 dwg, 4 ex
| Title | Year | Author | Number |
|---|---|---|---|
| METHOD FOR DIRECTED DELIVERY OF DNA INTO TUMOR AND STEM CELLS | 2008 |
|
RU2408607C2 |
| MOLECULAR CONJUGATES WITH POLYCATIONIC SECTION AND LIGAND FOR DELIVERY OF DNA AND RNA INTO CELL AND CELL NUCLEUS | 2009 |
|
RU2537262C2 |
| MEAN FOR INTRACELLULAR DELIVERY OF NUCLEIC ACIDS TO CELLS OF MAMMALS | 2014 |
|
RU2572575C1 |
| TREATMENT AND PREVENTION OF NEURODGENERATIVE DISEASES WITH USE OF GENE THERAPY | 2008 |
|
RU2471487C2 |
| PEPTIDES FOR INTRACELLULAR DELIVERY OF NUCLEIC ACIDS | 2020 |
|
RU2771605C2 |
| COMPOSITION INHIBITING EXPRESSION OF INTERLEUKIN-4 AND INTERLEUKIN-13 GENES FOR THERAPY OF ALLERGIC RHINITIS | 2018 |
|
RU2710895C1 |
| METHOD FOR PRODUCTION OF AMPHIPHILIC BLOCK COPOLYMERS N, N-DIMETHYLAMINOETHYL METHACRYLATE FOR NUCLEIC ACID DELIVERY TO LIVING CELLS | 2014 |
|
RU2617059C2 |
| METHOD OF PRODUCING PLASMID DNA IN POLYMER NANOSPHERES FOR DELIVERY | 2022 |
|
RU2817116C1 |
| COMPOSITION OF DELIVERY SYSTEM BASED ON CONJUGATE FOR RNA-INTERFERENCE POLYNUCLEOTIDE DELIVERY TO LIVER CELL AND PROCESS FOR ITS PREPARATION | 2011 |
|
RU2623160C9 |
| BIODEGRADABLE CATIONIC POLYMERS | 2005 |
|
RU2440380C2 |
