PhI p 5a DERIVATIVES HAVING DECREASED ALLERGENIC CAPACITY AND RETAINED T-CELLULAR REACTIVITY Russian patent published in 2009 - IPC C07K14/415 A61K36/00 C12N15/29 C12N15/63 C12P21/00 A61P37/00 

FIELD: medicine.

SUBSTANCE: invention includes obtaining and applying the versions of allergens of 5 Pooideae group, which are characterised by decreased IgE reactivity in comparison to known wild-type allergens and at the same time by essentially retained reactivity in comparison to T-lymphocytes. Versions of allergens, as per the invention, do not have at least one section or a combination of sections corresponding to amino-acid sequence of sections Phl p5a 94-113 or 175-198, which is given in the description. Versions of allergens have been obtained by gene-engineering methods. In the invention is opened DNA molecule encoding the version of allergen, recombinant expression vector, host organism, expression version of allergen and method of obtaining the version of allergen by using the above described means. Such hypoallergic versions of allergens can be used as a remedy against allergies determined by allergens of 5 Pooideae group for specific immunotherapy (hyposensitisation) of the patients having grass pollen allergy or for preventive immunotherapy of grass pollen allergies by using pharmaceutical composition.

EFFECT: preparations based on versions of allergens, as per the invention, have decreased IgE reactivity and the retained reactivity in relation to T-lymphocytes.

12 cl, 17 dwg, 3 tbl