FIELD: medicine.
SUBSTANCE: nucleic acid molecule encodes a homodimeric protein from two identical amino acid chains, each of which includes: (1) a signal peptide, (2) a directing unit, (3) a dimerization motif, and (4) an antigenic unit. The said directing unit consists of an amino acid sequence having at least 80% sequence identity with amino acid sequence 24-93 of SEQ ID NO: 1. The said antigenic unit includes an amino acid sequence derived from early human papillomavirus E6 (HPV16) and/or HPV18 proteins and an amino acid sequence derived from the early E7 protein from HPV16 and/or HPV18.
EFFECT: inventions allow to induce a specific and strong immune response to HPV by presenting APCs with the cells of immunogenic epitopes of HPV genes products and can be used as therapeutic compounds in treatment of various diseases caused by HPV, such as cancers and infectious diseases.
25 cl, 6 dwg, 4 ex
| Title |
Year |
Author |
Number |
| VACCINE COMPOSITION APPLICABLE IN HPV AND HEPATITIS VIRUS INFECTIONS, AND METHOD FOR PREPARING IT |
2009 |
- Ehlla Krishna Murtkhi
- Sumatkhi Kandasvami
|
RU2509570C2 |
| CPG AMPHIPHILES AND APPLICATIONS THEREOF |
2019 |
- Demuth, Peter, C.
- Steinbuck, Martin
|
RU2823677C2 |
| COMPOSITION COMPRISING LACTIC ACID BACTERIA, AN ORAL PHARMACEUTICAL COMPOSITION FOR TREATING HPV INFECTION AND/OR HPV-ASSOCIATED TUMORS AND AN AGENT INDUCING MUCOSAL IMMUNITY |
2016 |
- Kawana, Kei
- Igimi, Shizunobu
|
RU2728788C2 |
| HOMODIMER PROTEIN CONSTRUCTION |
2011 |
- Ruffini Per Adelki
- Bogen Byarne
- Fredriksen Agnete Brunsvik
|
RU2624041C2 |
| NUCLEIC ACID MOLECULE ENCODING HPV 31 L1, EXPRESSION VECTOR, HOST CELL, VIRUS-LIKE PARTICLE AND METHOD OF ITS OBTAINMENT, VACCINE, PHARMACEUTICAL COMPOSITION AND METHODS INVOLVING THEM |
2004 |
- Jansen Katrin U.
- Shul'Ts Loren D.
- Niper Majkl P.
- Markus Genri Z.
|
RU2356943C2 |
| FUSION PROTEINS FOR APPLICATION AS IMMUNOGENIC AMPLIFYING AGENTS TO INDUCE ANTIGEN-SPECIFIC T-CELL RESPONSE |
2013 |
|
RU2631002C2 |
| OPTIMISED EXPRESSION LI HPV45 IN YEAST |
2004 |
- Brajan Dzhanin T.
- Braunlou Mishell K.
- Shul'Tts Loren D.
- Jansen Katrin U.
|
RU2360001C2 |
| VECTORS FOR MULTIPLE GENE EXPRESSION |
2008 |
- Sil'Vestr Natali
- Shmitt Doris
|
RU2462513C2 |
| OPTIMISED EXPRESSION OF HPV 58 L1 IN YEAST |
2004 |
- Brajan Dzhanin T.
- Braunlou Mishell K.
- Shul'Ts Loren D.
- Van Sin'-Min'
- Jansen Katrin U.
|
RU2370538C2 |
| RECOMBINANT VACCINE FOR PREVENTION OF HUMAN PAPILLOMAVIRUS INFECTION AND METHOD OF ITS PREPARATION |
2014 |
- Krymskij Mikhail Aleksandrovich
- Borisov Ivan Andreevich
- Jakovlev Mikhail Simeonovich
- Mel'Nikov Vladimir Alekseevich
|
RU2546243C1 |
