INHIBITORS OF HEPATITIS C VIRUS HAVING RODLIKE CHAIN AND COMPRISING {2-[4-(BIPHENYL-4-YL)-1H-IMIDAZO-2-YL]PYRROLIDIN-1-CARBONYLMETHYL}AMINE FRAGMENT Russian patent published in 2017 - IPC C07D401/14 C07D401/04 A61K31/4439 A61K31/496 A61P31/14 

FIELD: pharmacology.

SUBSTANCE: invention relates to compound of formula (IV) or to pharmaceutically acceptable salt thereof, wherein R1 is selected from C_1-6alkyl, optionally substituted with hydroxy or methoxy, and tetrahydropyran; R² is a hydrogen atom; R³ is -C(O) OC_1-6alkyl; R⁴ is methyl, methoxy or -CH₂OCH₃; R⁷ is selected from atom of fluoro, chloro, -CF₃ and -OCF₃; R⁸ independently represents methyl or hydroxymethyl; R⁹ is selected from -NHCH₃, cyclopropyl, 2.2-dimethylcyclopropyl, tert-butyl, C_1-6alkyl substituted with -OH, and imidazolyl; R¹⁰ is hydrogen atom or hydroxymethyl; a takes on a value of 1 or 2; and b takes on a value of 1 or 2. The invention also relates to heterocyclic compound of formula (V), specific compound, pharmaceutical composition based on compound of formulas (IV) or (V), method for preparing a target compound, intermediate compound, as well as to application of the produced compounds and method for inhibiting hepatitis C virus replication.

EFFECT: new heterocyclic compounds are obtained, useful in the treatment of a viral infection of hepatitis C virus.

15 cl, 1 dwg, 29 tbl, 24 ex