NEW GROUP OF PEPTIDES FOR TREATMENT OF FEMALE SEXUAL DYSFUNCTION Russian patent published in 2017 - IPC C07K5/08 C07K7/06 A61K38/06 A61K38/08 A61P15/00 

FIELD: pharmacology.

SUBSTANCE: peptides of general formula (I) are proposed: A-Thr-Lys-Hyp-B-C-D-X, where A is 0, Met, Met(O), Thr, Ala, His, Phe, Lys, Gly; B is 0, Gly, Asp, Trp, Gln, Asn, Tyr, Hyp, Arg; C is 0, Arg, Phe, Tyr, Gly, His, Hyp, Lys; D is 0, Val, Gly, Tyr, Trp, Phe, His; X is OH, OCH₃, NH₂; where 0 is the absence of amino acid residue, provided that if A≠0, then B, and/or C, and/or D≠0, if B≠0, then C and/or D≠0, excluding tetrapeptides, as well as peptides Phe-Thr-Lys-Hyp-Gly, Thr-Lys-Hyp-Hyp-Arg, Thr-Lys-Hyp-Arg-Gly. Pharmaceutical compositions containing these peptides and their application for treatment of women with a marked decrease in libido or with a complete lack of libido, with orgasmic dysfunction, sexual dysfunction not caused by organic disorders or diseases, HSDD, FSAD or FSIAD are also proposed.

EFFECT: stimulated sexual properties and increased stability during storage.

13 cl, 6 dwg, 4 tbl, 3 ex