METHOD FOR SIMULATION OF LESSER CIRCULATION HYPERTENSION Russian patent published in 2017 - IPC G09B23/28 

FIELD: medicine.

SUBSTANCE: male Wistar rats aged 10-12 months are used, that are subject to tracheotomy along the median line below the thyroid isthmus. Then, a silicone tube, 1 cm long, with the outside diameter of 2 mm with obtuse rounded ends is directed into the tracheal lumen. The upper edge of the inserted tube is compared with the lower edge of the tracheotomy wound, the conductor is removed while holding the tube, the tracheotomy is sutured by an U-shaped suture through the upper and lower tracheal semicircles with one-stage tube fixation to the inner surface of the tracheal wall. For this, the thread is conducted from the outside through the membrane portion between the 6th and the 7th tracheal cartilages with the needle exit into the tracheal lumen, then the needle is drawn along the upper edge of the silicone tube, the next injection is carried out from the inside outwards, through the membrane portion of the anterior wall of the trachea between the 8th and the 9th cartilages, pricking out on the anterior wall of the trachea. This manipulation is also carried out on the other side, in the reverse order. The knot is fixed on the inter-cartilage gap between the 6th and the 7th cartilages of the trachea. Sternohyoids are joined by a nodular suture, the skin is sutured continuously.

EFFECT: method allows to obtain a model of lesser circulation hypertension with characteristic signs of the clinical course of the disease.

1 ex, 4 dwg