FIELD: medicine.
SUBSTANCE: invention relates to medicine, namely to experimental cardiology. To simulate chronic thromboembolic pulmonary hypertension (CTPH), embolizing particles in the form of autologous blood clots are intravenously injected into the rat, encapsulated in alginate microcapsules with a diameter of 130–400 mcm with a ratio by volume of blood clots and sodium alginate from 1:7 to 1:3 in an amount of 200–250 mcl of microcapsules at least 4 times with an interval of at least 2 days.
EFFECT: this method allows the most complete reproduction of pathogenetic processes during the formation of CTPH, ensuring in laboratory animals pathophysiological and structural changes in the pulmonary vascular bed corresponding to CTPH.
1 cl, 7 dwg, 3 ex
| Title | Year | Author | Number |
|---|---|---|---|
| METHOD FOR MODELLING CHRONIC THROMBOEMBOLIC PULMONARY HYPERTENSION IN LARGE ANIMALS | 2023 |
|
RU2811651C1 |
| METHOD FOR MODELING PULMONARY ARTERY THROMBOSIS IN CONDITIONS OF VENOUS THROMBOSIS | 2021 |
|
RU2770355C1 |
| METHOD OF INHIBITING THROMBUS FORMATION AND ACCELERATION OF FIBRINOLYSIS WITH DNA APTAMERS INHIBITING ACTIVITY OF THROMBIN IN EXPERIMENT | 2014 |
|
RU2559545C1 |
| APPLICATION OF DINITROSYL IRON COMPLEX WITH GLUTATHIONE-GS {(GS)2FE2(NO)4} FOR THE TREATMENT OF PATIENTS WITH PULMONARY ARTERIAL HYPERTENSION | 2022 |
|
RU2804734C1 |
| METHOD OF ACCESS TO LARGE VEINS OF UPPER EXTREMITIES (VBASILICA AND VCEPHALILCA) FOR CARRYING OUT DIAGNOSTIC AND THERAPETIC INTERVENTIONAL INTERFERENCES | 2016 |
|
RU2613562C1 |
| METHOD OF DISTANT HEPATOCYTE REGENERATION STIMULATION | 2015 |
|
RU2590859C1 |
| METHOD FOR SIMULATING RENOPARENCHYMATOUS ARTERIAL HYPERTENSION IN RATS | 2012 |
|
RU2507593C1 |
| METHOD FOR EVALUATION OF THE VOLUME OF PULMONARY PERFUSION DISORDERS | 2017 |
|
RU2653994C1 |
| METHOD OF TREATING CARDIOVASCULAR PATIENTS AFTER SUFFERING ACUTE CORONARY SYNDROME AND CARDIOSURGICAL INTERVENTIONS | 2019 |
|
RU2715209C1 |
| METHOD FOR CONTROLLED PULMONARY THROMBOENDARTERECTOMY IN THE TREATMENT OF CHRONIC THROMBOEMBOLIC PULMONARY HYPERTENSION | 2022 |
|
RU2794557C1 |
