FIELD: chemistry.
SUBSTANCE: invention relates to a compound of formula I or tautomer thereof or pharmaceutically acceptable salts thereof, where R2 is C1-3-alkyl or cyclopropyl; R9 is a halogen, C1-3-alkyl, -O-(C1-3-alkyl), -S-(C1-3alkyl) or CF3 and p equals 1-2. The disclosed compounds are Aurora protein kinase inhibitors. Said compounds can be used in a method of inhibiting Aurora protein kinase activity. The invention also discloses pharmaceutically acceptable compositions containing such compounds; and a method of treating proliferative disorders in a patient using said compounds.
EFFECT: more effective use of the compounds.
11 cl, 7 tbl, 20 ex
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Authors
Dates
2011-08-27—Published
2006-11-03—Filed