AMINOPYRIMIDINES AS KINASE INHIBITORS Russian patent published in 2011 - IPC C07D403/12 A61K31/506 A61P35/00 

Abstract RU 2427578 C2

FIELD: chemistry.

SUBSTANCE: invention relates to a compound of formula I or tautomer thereof or pharmaceutically acceptable salts thereof, where R2 is C1-3-alkyl or cyclopropyl; R9 is a halogen, C1-3-alkyl, -O-(C1-3-alkyl), -S-(C1-3alkyl) or CF3 and p equals 1-2. The disclosed compounds are Aurora protein kinase inhibitors. Said compounds can be used in a method of inhibiting Aurora protein kinase activity. The invention also discloses pharmaceutically acceptable compositions containing such compounds; and a method of treating proliferative disorders in a patient using said compounds.

EFFECT: more effective use of the compounds.

11 cl, 7 tbl, 20 ex

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RU 2 427 578 C2

Authors

Binch Khehjli

Mortimor Majkl

Frajss Dam'En

Rezerford Ehlister

Dates

2011-08-27Published

2006-11-03Filed