FIELD: chemistry.
SUBSTANCE: invention relates generally to a compound of the following formula
,
as well as to pharmaceutical compositions containing such compounds, and the use of such compounds for inhibiting the kinase function of CHK1 and for treating CHK1 mediated diseases and conditions.
EFFECT: technical result: obtaining novel compounds, suitable for the treatment of proliferative diseases, such as cancer, by inhibiting the kinase function of CHK1.
26 cl, 7 tbl
| Title | Year | Author | Number |
|---|---|---|---|
| 5-(PYRIDINE-2-YLAMINO)-PYRASIN-2-CARBONITRILE COMPOUNDS AND THEIR THERAPEUTIC APPLICATION | 2012 |
|
RU2641693C2 |
| COMBINATION OF CHEKPOINT-KINASE 1 INHIBITORS AND WEE 1 KINASE INHIBITORS | 2011 |
|
RU2627841C2 |
| COMBINED THERAPY WITH (2R,Z)-2-AMINO-2-CYCLOHEXYL-N-(5-(1-METHYL-1H-PIRAZOLE-4-YL)-1-OXO-2,6-DIHYDRO-1H-[1,2]DIAZEPINO[4,5,6-cd]INDOLE-8-YL)ACETAMIDE | 2007 |
|
RU2409361C2 |
| PHOSPHORUS AMIDATE DERIVATIVES OF 5-FLUORO-2'-DEOXYURIDINE APPLICABLE FOR TREATING CANCER | 2012 |
|
RU2614406C2 |
| RAD3 POLYPEPTIDE ATR HOMOLOGUES, POLYNUCLEUTIDES AND RELATED METHODS AND MATERIALS | 1996 |
|
RU2252256C2 |
| METHOD OF PREPARING COMPOUND | 2014 |
|
RU2672725C2 |
| INHIBITORS OF CELL CYCLE CHECKPOINT KINASE 1 FOR AMPLIFICATION OF DNA-DAMAGING AGENTS | 2010 |
|
RU2567044C2 |
| METHOD OF TREATING CANCER USING A COMBINATION OF CHK1 AND ATR INHIBITORS | 2015 |
|
RU2736219C2 |
| CHEMICAL COMPOUNDS | 2014 |
|
RU2644769C2 |
| PEPTIDE PROTECTION AGAINST ULTRAVIOLET LIGHT TOXICITY | 2010 |
|
RU2565535C2 |
